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Retatrutide

Retatrutide

GLP-1

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€34per vial10% OFF

💰 Buy the kit of 10 for €189 — save 44%

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Add Bacteriostatic Water?

Required for reconstituting lyophilized peptides

99%+ Purity

Third-Party Tested

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⚠️ RESEARCH USE ONLY

Strictly for laboratory research purposes. Not intended for human consumption.

Overview

Retatrutide (LY3437943) is a next-generation triple agonist peptide targeting GIP (glucose-dependent insulinotropic polypeptide), GLP-1 (glucagon-like peptide-1), and glucagon receptors simultaneously. It represents one of the most advanced metabolic research compounds available, demonstrating exceptional results in preclinical and clinical studies on body weight regulation and metabolic function.

Mechanism of Action

  • ▸Triple receptor agonism: activates GIP, GLP-1, and glucagon receptors
  • ▸Reduces caloric intake via hypothalamic appetite suppression
  • ▸Increases energy expenditure through glucagon receptor activation
  • ▸Enhances insulin secretion in a glucose-dependent manner
  • ▸Promotes hepatic fat oxidation and reduces liver steatosis

Key Research Findings

  • ▸Phase 2 trials demonstrated up to 24% body weight reduction over 48 weeks
  • ▸Superior weight loss vs. semaglutide and tirzepatide in head-to-head comparisons
  • ▸Significant improvements in fasting glucose and HbA1c levels
  • ▸Reduction in visceral and hepatic adiposity
  • ▸Favorable cardiovascular risk marker profile in metabolic syndrome models

Research Applications

Retatrutide is used in advanced metabolic research to study obesity pathophysiology, energy homeostasis, hepatic lipid metabolism, and multi-receptor agonism pharmacology. It is a primary reference compound for next-generation GLP/GIP/glucagon triple agonist development.

Reconstitution

Reconstitute with bacteriostatic water (0.9% benzyl alcohol). Add solvent slowly along the vial wall. Gently swirl — do not shake. Allow 5–10 minutes for complete dissolution.

Storage

Lyophilized: Store at –20°C, protected from light. Stable for up to 24 months. Reconstituted: 2–8°C, use within 28 days.

Purity & Testing

≥99% by HPLC · Endotoxin tested · Third-party CoA available on request

⚠️ Research Use Only

All information provided is for scientific research purposes only. This product is not intended for human consumption, medical use, diagnosis, or treatment. For use by qualified researchers only. By purchasing, you confirm compliance with all applicable laws and regulations.