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Semaglutide

Semaglutide

GLP-1

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Add Bacteriostatic Water?

Required for reconstituting lyophilized peptides

99%+ Purity

Third-Party Tested

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⚠️ RESEARCH USE ONLY

Strictly for laboratory research purposes. Not intended for human consumption.

Overview

Semaglutide is a GLP-1 receptor agonist peptide analog of human GLP-1 with 94% structural homology and an extended half-life achieved through fatty acid conjugation. It is one of the most extensively studied peptides in metabolic and cardiovascular research, approved clinically under the brand names Ozempic® and Wegovy®.

Mechanism of Action

  • ▸Selective GLP-1 receptor agonist with high binding affinity
  • ▸Suppresses appetite via central (hypothalamic) and peripheral mechanisms
  • ▸Stimulates glucose-dependent insulin secretion from pancreatic beta cells
  • ▸Inhibits glucagon release during hyperglycemia
  • ▸Delays gastric emptying, reducing postprandial glucose spikes
  • ▸Half-life ~168 hours due to albumin-binding fatty acid chain

Key Research Findings

  • ▸SUSTAIN & STEP trials: 10–17% average body weight reduction
  • ▸Significant HbA1c reduction (1.5–2.0%) in T2DM models
  • ▸PIONEER-6 / SUSTAIN-6: demonstrated cardiovascular risk reduction
  • ▸Reduces hepatic fat content and markers of NASH
  • ▸Neuroprotective effects studied in Parkinson's and Alzheimer's models

Research Applications

Used extensively in metabolic disease research, obesity pharmacology, cardiovascular risk reduction studies, and increasingly in neurodegeneration and addiction research. Ideal reference compound for GLP-1 agonist class comparisons.

Reconstitution

Reconstitute with bacteriostatic water. Add 1–2 mL slowly, swirl gently until fully dissolved. Avoid vigorous shaking to prevent degradation.

Storage

Lyophilized: –20°C, up to 24 months. Reconstituted: 2–8°C, stable for 28 days. Do not freeze reconstituted solution.

Purity & Testing

≥99% by HPLC · Mass spec verified · Third-party CoA available

⚠️ Research Use Only

All information provided is for scientific research purposes only. This product is not intended for human consumption, medical use, diagnosis, or treatment. For use by qualified researchers only. By purchasing, you confirm compliance with all applicable laws and regulations.